SYNTHESIS AND CYTOTOXIC ACTIVITY OF NEW ISOTHIAZOLO[5,4-D]PYRIMIDINE DERIVATIVES

Authors
LIPNICKA U REGIEC A MACHON Z
Citation
U. Lipnicka et al., SYNTHESIS AND CYTOTOXIC ACTIVITY OF NEW ISOTHIAZOLO[5,4-D]PYRIMIDINE DERIVATIVES, Die Pharmazie, 49(9), 1994, pp. 642-646
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
49
Issue
9
Year of publication
1994
Pages
642 - 646
Database
ISI
SICI code
0031-7144(1994)49:9<642:SACAON>2.0.ZU;2-P
Abstract
The synthesis of new 5-amino-3-methylisothiazolo[5,4-d]pyrimidines ser ies is reported. The cytotoxic activity of these compounds has been de termined on the two tumor cell lines (P-388 and KB). Two representativ e compounds 7 and 8 displayed a significant cytotoxic action. The resu lts point a possible involvement of structural features in the inhibit ion effect against tumors.