SOLUBILIZATION OF SPIRONOLACTONE BY COSOLVENTS

Authors
PRAMAR YV DASGUPTA V
Citation
Yv. Pramar et V. Dasgupta, SOLUBILIZATION OF SPIRONOLACTONE BY COSOLVENTS, Die Pharmazie, 49(9), 1994, pp. 661-665
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
49
Issue
9
Year of publication
1994
Pages
661 - 665
Database
ISI
SICI code
0031-7144(1994)49:9<661:SOSBC>2.0.ZU;2-S
Abstract
The purpose of this investigation was to improve the solubility of spi ronolactone (1) for use in oral pediatric formulations. The cosolvent approach was used to solubilize 1, using combinations of ethanol, prop ylene glycol, polyethylene glycol 400, glycerin, and 70% w/w sorbitol. The solubility of 1 in several cosolvent blends was determined. The r esults obtained indicate that the solubility of 1 can indeed be increa sed by as much as 70-fold, by the cosolvent approach. Certain pairs of solvents exhibited a synergistic increase in solubility. The Yalkowsk y equation was used to model the solubility increases. Correlations be tween solubility and the dielectric constant of the cosolvent blends w ere investigated.