IMMUNOMODULATORY PROPERTIES OF 9-(2-PHOSPHONOMETHOXYETHYL)-ADENINE (PMEA)

Authors
OTOVA B ZIDEK Z HOLY A VOTRUBA I FRANKOVA D
Citation
B. Otova et al., IMMUNOMODULATORY PROPERTIES OF 9-(2-PHOSPHONOMETHOXYETHYL)-ADENINE (PMEA), Folia biologica, 40(4), 1994, pp. 185-192
Citations number
17
Categorie Soggetti
Biology
Journal title
Folia biologica → ACNP
ISSN journal
00155500
Volume
40
Issue
4
Year of publication
1994
Pages
185 - 192
Database
ISI
SICI code
0015-5500(1994)40:4<185:IPO9(>2.0.ZU;2-D
Abstract
PMEA was found to influence the immune system of the mouse and rat in vivo in different ways. PMEA administered after injection of parental splenocytes to F-1 recipients reduced the development of local graft-v ersus-host reaction (GVHR). However, PMEA treatment of donors of splen ocytes had no influence on GVHR. Modifications in the immune system tr iggered by PMEA were confirmed in the rat model by evaluation of subse ts of white blood cells isolated from peripheral blood by a set of mon oclonal antibodies. Enhanced formation of nitric oxide (NO) was found in both unconditioned and LPS-stimulated macrophage cultures on day 14 of the drug treatment of rats.