NUCLEAR AND NUCLEOLAR KINETICS IN MULTINUCLEATE OSTEOCLASTS IN THE CHICK DEVELOPMENT AND AFTER THE HORMONAL TREATMENT

This study demonstrates the changes in the number of nuclei, number of nucleolar silver-stained granules, and the incidence of the morpholog ical types of nucleoli in the chick osteoclast ontogeny and after the parathormone and calcitonin treatment. The number of cell nuclei was i ncreased during the ontogeny and after the parathormone treatment. The number of silver-stained nucleolar granules decreased during the onto geny. Parathormone and calcitonin did not influence the number of silv er-stained granules, and an insignificant effect on the number of nucl ei was detected after the calcitonin application. The compact nucleoli and/or nucleoli with nucleolonema prevailed in all the investigated d evelopmental stages of the chick. The nucleoli in multinucleate osteoc lasts are active from the morphological point of view. A relationship between the nucleolar function and the number of nuclei in one cell co uld be possible.