Two cases of yellow nail syndrome (a triad of yellow dystrophic nails,
chronic lymphedema and pleural effusion) are described which demonstr
ate long-term control of recurrent pleural effusions by tetracycline p
leurodesis. Neither patient developed problems as a result of the proc
edure enabling us to conclude that tetracycline pleurodesis is effecti
ve in managing reaccumulating pleural fluid in yellow nail syndrome an
d may avoid loss of lung function due to pleural peel.