IMMUNOTOXINS IN THE THERAPY OF CANCER - FROM BENCH TO CLINIC

Authors
GHETIE V VITETTA E
Citation
V. Ghetie et E. Vitetta, IMMUNOTOXINS IN THE THERAPY OF CANCER - FROM BENCH TO CLINIC, Pharmacology & therapeutics, 63(3), 1994, pp. 209-234
Citations number
127
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology & therapeutics → ACNP
ISSN journal
01637258
Volume
63
Issue
3
Year of publication
1994
Pages
209 - 234
Database
ISI
SICI code
0163-7258(1994)63:3<209:IITTOC>2.0.ZU;2-2
Abstract
This review presents only those contributions that have progressed fro m the bench to the clinic using murine monoclonal antibodies coupled c hemically to toxins, their subunits or ribosome-inactivating proteins. The rationale and progress in the development, characterization, prec linical testing and clinical trials are discussed.