ANGIOGENESIS INHIBITION - A REVIEW

In this review we discuss the concept of anti-angiogenesis, which is t he inhibition of neovascularization. Anti-angiogenic agents are viewed from the standpoint of their effect on various elements of the angiog enic process, including induction of vascular discontinuity, endotheli al cell movement, endothelial cell proliferation, and three-dimensiona l restructuring of patent vessels. An effort is made to place the many different approaches to anti-angiogenesis research into a comprehensi ble structure, in order to identify problems of evaluation and interpr etation, thereby providing a clearer basis for determining promising a nd needed directions for further investigation.