Fe. Romesberg et Db. Collum, LITHIUM DIALKYLAMIDE MIXED AGGREGATION - MNDO COMPUTATIONAL STUDY OF SALT AND SOLVENT DEPENDENCIES, Journal of the American Chemical Society, 116(20), 1994, pp. 9187-9197
Mixed aggregation of lithium diaikylamides with various LiX salts is s
tudied by semiempirical (MNDO) computational methods. The relative sta
bilities of mixed aggregates of lithium diisopropylamide and lithium 2
,2,6,6-tetramethylpiperidide with LiCl as well as the enolates derived
from acetone, cyclohexanone, and 2,4-dimethylpentanone are described.
The unsolvated forms are compared with the analogous structures solva
ted by tetrahydrofuran and hexamethylphosphoramide. The structural typ
es studied include mixed cyclic dimers (R(2)NLi-LiX), trimers [(R(2)NL
i)2(LiX)2], and tetramers [(R(2)NLi)(2)(LiX)(2)]; 3-rung ladders [(R(2
)NLi)(2)(LiX)] and 4-rung ladders [(R(2)NLi)(2)(LiX)(2)]; two isomeric
open dimer topologies corresponding to cyclic dimers fragmented at N-
Li and X-Li bonds; triple ions (R(2)NLiX(-)//Li-+). A complex interpla
y of steric effects appears to be the dominant influence on the mixed
aggregate structures and relative stabilities.