LACK OF AFB(1)-INDUCED MUTAGENICITY IN THE IN-VITRO HEPATOCYTE MICRONUCLEUS ASSAY - INVESTIGATION OF POSSIBLE MECHANISMS

Authors
MULLER K KASPER P MULLER L
Citation
K. Muller et al., LACK OF AFB(1)-INDUCED MUTAGENICITY IN THE IN-VITRO HEPATOCYTE MICRONUCLEUS ASSAY - INVESTIGATION OF POSSIBLE MECHANISMS, Toxicology in vitro, 8(4), 1994, pp. 533-534
Citations number
6
Categorie Soggetti
Toxicology
Journal title
Toxicology in vitro → ACNP
ISSN journal
08872333
Volume
8
Issue
4
Year of publication
1994
Pages
533 - 534
Database
ISI
SICI code
0887-2333(1994)8:4<533:LOAMIT>2.0.ZU;2-T
Abstract
Several mechanistic experiments were carried out to investigate negati ve results obtained with aflatoxin B-1 (AFB(1)) in the in vitro hepato cyte micronucleus assay. The data showed that the lack of AFB(1)-induc ed mutogenicity was not due to deficient metabolic activation of the m ycotoxin or to an inefficiency of the test protocol. It appeared that the cytotoxic actions of AFB(1), specifically the interference with he patocyte proliferation, prevented the formation of micronuclei.