NEW STEREOSPECIFIC METHOD OF SYNTHESIS OF [SP] AND [RP]-DINUCLEOSIDE-(3',5')METHANEPHOSPHONATES

Authors
WOZNIAK LA PYZOWSKI J WIECZOREK M STEC WJ
Citation
La. Wozniak et al., NEW STEREOSPECIFIC METHOD OF SYNTHESIS OF [SP] AND [RP]-DINUCLEOSIDE-(3',5')METHANEPHOSPHONATES, Journal of organic chemistry, 59(20), 1994, pp. 5843-5846
Citations number
52
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
20
Year of publication
1994
Pages
5843 - 5846
Database
ISI
SICI code
0022-3263(1994)59:20<5843:NSMOSO>2.0.ZU;2-G
Abstract
Using a stereoretentive reaction between diastereomerically pure 5'-O- DMT-(N-protected) nucleoside 3'-O-(Se-methyl methanephosphonoselenolat e)s and 3'-O-acetyl-(N-protected) nucleosides, diastereomerically pure dinucleoside-(3',5') methanephosphonates as well as ''all-Rp'' and '' all-Sp'' trimers, tetramers, and pentamers were synthesized.