LIBRARY-BASED LEAD COMPOUND DISCOVERY - ANTIOXIDANTS BY AN ANALOGOUS SYNTHESIS DECONVOLUTIVE ASSAY STRATEGY

Authors
KURTH MJ RANDALL LAA CHEN CX MELANDER C MILLER RB MCALISTER K REITZ G KANG R NAKATSU T GREEN C
Citation
Mj. Kurth et al., LIBRARY-BASED LEAD COMPOUND DISCOVERY - ANTIOXIDANTS BY AN ANALOGOUS SYNTHESIS DECONVOLUTIVE ASSAY STRATEGY, Journal of organic chemistry, 59(20), 1994, pp. 5862-5864
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
20
Year of publication
1994
Pages
5862 - 5864
Database
ISI
SICI code
0022-3263(1994)59:20<5862:LLCD-A>2.0.ZU;2-0
Abstract
A two-part demonstration project is reported which utilized analogous synthesis to reliably deliver a 27-analogue Library which was then eva luated for antioxidative efficiency in a resin-free (ferric thiocyanat e assay) deconvolutive assay.