EFFECT OF RETINOIC ACID ON HL-60 CELLS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

Authors
SEMMEL M MACHO A COULAUD D ALILECHE A PLAISANCE S AGUILAR J JASMIN C
Citation
M. Semmel et al., EFFECT OF RETINOIC ACID ON HL-60 CELLS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, Blood, 84(8), 1994, pp. 2480-2488
Citations number
38
Categorie Soggetti
Hematology
Journal title
Blood → ACNP
ISSN journal
00064971
Volume
84
Issue
8
Year of publication
1994
Pages
2480 - 2488
Database
ISI
SICI code
0006-4971(1994)84:8<2480:EORAOH>2.0.ZU;2-A
Abstract
HL-60 cells infected with human immunodeficiency virus type 1 (HIV 1) can be induced to differentiate along the granulocyte pathway by retin oic acid. In these cells, HIV mRNA synthesis is stimulated, but synthe sis of viral proteins and virus replication are blocked and HIV-infect ed cells die after becoming apoptotic and/or vacuolized. (C) 1994 by T he American Society of Hematology.