TRIPHENYLTIN AS INDUCTOR OF MITOCHONDRIAL-MEMBRANE PERMEABILITY TRANSITION

Authors
ZAZUETA C REYESVIVAS H BRAVO C PICHARDO J CORONA N CHAVEZ E
Citation
C. Zazueta et al., TRIPHENYLTIN AS INDUCTOR OF MITOCHONDRIAL-MEMBRANE PERMEABILITY TRANSITION, Journal of bioenergetics and biomembranes, 26(4), 1994, pp. 457-462
Citations number
37
Categorie Soggetti
Biophysics,"Cytology & Histology
Journal title
Journal of bioenergetics and biomembranes → ACNP
ISSN journal
0145479X
Volume
26
Issue
4
Year of publication
1994
Pages
457 - 462
Database
ISI
SICI code
0145-479X(1994)26:4<457:TAIOMP>2.0.ZU;2-Y
Abstract
The effect of triphenyltin on mitochondrial Ca2+ content was studied. It was found that this trialkyltin compound induces an increase in mem brane permeability that leads to Ca2+ release, drop of the transmembra ne potential, and efflux of matrix proteins. Interestingly, cyclospori n A was unable to inhibit triphenyltin-induced Ca2+ release. Based on these results it is proposed that the hyperpermeable state is produced by modification of 2.25 mmol of membrane thiol groups.