Rjo. Davies et al., PLASMA-INSULIN AND LIPID-LEVELS IN UNTREATED OBSTRUCTIVE SLEEP-APNEA AND SNORING - THEIR COMPARISON WITH MATCHED CONTROLS AND RESPONSE TO TREATMENT, Journal of sleep research, 3(3), 1994, pp. 180-185
Obstructive sleep apnoea (OSA), and snoring are associated with corona
ry heart disease. To assess whether OSA or snoring may contribute to t
his by raising fasting lipid or insulin levels, venous fasting total c
holesterol, triglyceride, very-low-density lipoprotein, low-density li
poprotein, high-density lipoprotein, and insulin were measured in 15 u
ntreated OSA patients and 18 snorers. Each of these subjects was indiv
idually matched to a control of the same sex, age +/- 10%, body index
+/- 15%, smoking and drinking habits. This produced study groups which
did not differ significantly by any of these criteria. Fasting venous
blood samples were collected at 06.30 hours following polysomnography
, and analysed blind of the subjects respiratory status. The OSA patie
nts were then treated with nasal continuous positive airway pressure.
In 10 of these subjects lipid and insulin levels were repeated after m
ore than three months treatment. Lipid and insulin levels were also re
measured in the controls matched to these 10 subjects. The end points
were compared with paired t-tests. There was no difference in any of t
he end points when the untreated OSA patients and the snorers were com
pared to their matched controls (P > 0.25 for all comparisons), and no
ne of the indices changed when OSA was corrected with nasal continuous
positive airway pressure (P > 0.25 for all comparisons). Patients wit
h obstructive sleep apnoea or snoring do not have significant fasting
hyperlipidaemia or hyperinsulinaemia when compared to carefully matche
d controls. These factors are therefore unlikely to be the cause of th
e excess cardiovascular mortality experienced by this patient group.