ANTIPHOSPHOLIPID AND ANTI-BETA(2) GLYCOPROTEIN ANTIBODIES IN MONOZYGOTIC TWIN SISTERS

Authors
CEVALLOS R DARNIGE L ARVIEUX J VEYSSIER P GRUEL Y
Citation
R. Cevallos et al., ANTIPHOSPHOLIPID AND ANTI-BETA(2) GLYCOPROTEIN ANTIBODIES IN MONOZYGOTIC TWIN SISTERS, Journal of rheumatology, 21(10), 1994, pp. 1970-1971
Citations number
16
Categorie Soggetti
Rheumatology
Journal title
Journal of rheumatology → ACNP
ISSN journal
0315162X
Volume
21
Issue
10
Year of publication
1994
Pages
1970 - 1971
Database
ISI
SICI code
0315-162X(1994)21:10<1970:AAAGAI>2.0.ZU;2-Y
Abstract
We describe an 18-year-old woman with primary antiphospholipid syndrom e whose monozygotic twin sister is as yet an asymptomatic carrier of t he lupus anticoagulant, anticardiolipin, and anti-beta(2) glycoprotein I (beta(2)GPI) antibodies. Serum concentrations of beta(2)GPI were no rmal in the patient and elevated in her sister. HLA and complement C4 phenotypes showed the presence of class II antigens DR7 and DRw53 and of a C4AQ0 allele. This supports the theory that a genetic predisposit ion may influence the appearance of these autoantibodies.