Surgery-namely, suture closure-is still the treatment of choice for pe
rforated peptic ulcers, despite the proven efficacy of Taylor's conser
vative approach. Such conservative management, however, has been prove
n less effective in high-risk patients and those with perforations mor
e than 12 h old. Here we suggest alternative laparoscopic treatments f
or perforated peptic ulcers. We have treated laparoscopically six pati
ents (one F, five M; mean age 57.6 years; range 31-81 years); the mean
duration of the operation was 52 min; the median hospital stay was 7
days (6-15 days); H-2-blockers, antibiotics, and fluids were administe
red in the p.o. course; the follow-ups range from 6 to 18 months. On t
he basis of our experience, the treatment of choice for perforated pep
tic ulcers is Taylor's conservative procedure and laparoscopic drainag
e of the abdominal cavity when there is mild peritoneal reaction (usua
lly less than 6 h from the onset of perforation). In case of remarkabl
e peritonitis (usually more than 12 h), it is mandatory to add an accu
rate lavage. When the site of perforation is concealed by the peritone
al inflammation it should not be searched; when visible, it might be o
bliterated with the round ligament or an omental tissue strand, partic
ularly if larger than 1 cm in diameter.