CONSECUTIVE SUCCESSFUL PREGNANCIES IN A COMBINED LIVER AND KIDNEY-TRANSPLANT RECIPIENT WITH TYPE-1 PRIMARY HYPEROXALURIA

Pregnancy is now a common, but high-risk event, in young women who hav e received transplants. Consequences to the fetus are known, but pregn ancy may also interfere with graft function, We report the outcome of two successive and successful pregnancies in a 29-year-old woman with type 1 hyperoxaluria, who received a combined liver and kidney transpl ant. Two healthy children were born at 35 and 37 weeks of gestation, w ith low birth weight. Liver function remained normal before, during, a nd after pregnancies up to 52 months after transplantation. Renal func tion was impaired before the first conception, worsened during both pr egnancies, and returned to the previous level in both immediate postpa rtum periods, However, renal function has declined 17 months after the last delivery. This report shows the feasibility of successive pregna ncies in multiple organ transplant recipients, but raises the question of long-term maternal kidney graft survival.