M. Ito et al., EFFECT OF CIMETIDINE AND OMEPRAZOLE ON GASTRIC-ULCER HEALING OF RATS WITH LIMITED FOOD-INTAKE TIME, European journal of pharmacology, 263(3), 1994, pp. 245-251
The effects of cimetidine, omeprazole and atropine sulfate on the heal
ing of acetic acid-induced gastric ulcers in rats with limited food in
take time (9:00-10:00 a.m. and 5:00-6:00 p.m.) were evaluated 15 days
after the acid injection. Oral repeated administration of cimetidine (
25-100 mg/kg twice daily) or omeprazole (10-50 mg/kg once daily) dose
dependently accelerated ulcer healing. Atropine sulfate (10 mg/kg twic
e daily, p.o.) was ineffective. A single oral administration of omepra
zole (50 mg/kg) or cimetidine (100 mg/kg) resulted in potent and long-
lasting anti-acid secretory and gastrin-releasing actions. The degree
and duration of anti-acid secretion by atropine sulfate were equal to
those of cimetidine, but the elevation of gastrin release by atropine
sulfate was weak and temporary. These results indicate that the gastri
c ulcers of rats with a limited food intake time are useful for evalua
ting the healing effects of cimetidine and omeprazole on gastric ulcer
s. In addition, the effects of both drugs may be related to the increa
sed gastrin release rather than to the reduced acid secretion.