REGULATION OF PROTEOLYTIC ACTIVITY IN TISSUES

Degradation of tissue proteins is controlled by multiple means. These include regulation of the synthesis of proteinases, activation of the zymogen forms, the activity of the mature proteinase, and the degradat ion of these enzymes and the substrates. Mature proteinases can be con trolled by pH, calcium ions, ATP, lipids and the formation of complexe s with other proteinases, proteoglycans, and inhibitors.