SYNTHESIS AND ANTITUMOR-ACTIVITY OF 6-METHYL DERIVATIVES OF FLAVONE-8-ACETIC ACID (FAA)

Authors
AITKEN RA BIBBY MC DOUBLE JA PHILLIPS RM SHARMA SK
Citation
Ra. Aitken et al., SYNTHESIS AND ANTITUMOR-ACTIVITY OF 6-METHYL DERIVATIVES OF FLAVONE-8-ACETIC ACID (FAA), Bioorganic & medicinal chemistry letters, 4(19), 1994, pp. 2313-2316
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
19
Year of publication
1994
Pages
2313 - 2316
Database
ISI
SICI code
0960-894X(1994)4:19<2313:SAAO6D>2.0.ZU;2-W
Abstract
A range of 16 derivatives of flavone-8-acetic acid (FAA) with a 6-meth yl substituent have been prepared and their anti-tumour activity evalu ated in vitro against a panel of human and murine tumour cell lines an d in vivo against MAC 15A. While many of the compounds show activity c omparable to FAA in vitro, this essentially disappears in vivo, possib ly due to degradation before the compounds can reach the tumour site.