SYNTHESIS, CHEMICAL HALF-LIFE AND DECOMPOSITION OF NEW N-3-(SUBSTITUTED) DERIVATIVES OF CCNU

Authors
GALLANT G SALVADOR R DULUDE H
Citation
G. Gallant et al., SYNTHESIS, CHEMICAL HALF-LIFE AND DECOMPOSITION OF NEW N-3-(SUBSTITUTED) DERIVATIVES OF CCNU, Bioorganic & medicinal chemistry letters, 4(19), 1994, pp. 2353-2358
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
19
Year of publication
1994
Pages
2353 - 2358
Database
ISI
SICI code
0960-894X(1994)4:19<2353:SCHADO>2.0.ZU;2-9
Abstract
A series of new N-3-(substituted) derivatives of CCNU was synthesized with the aim of producing more stable compounds with increased cytotox icity. The nitrosoureas produced in this study were much more stable i n aqueous medium than CCNU (15 to 100 times longer half-lives). The de composition of these nitrosoureas seems to be different in that they p roduce the original amine plus other decomposition products.