Background and Methods: Although studies have demonstrated that medica
l rehabilitation patients have many complications that warrant attenti
on, none has attempted to categorize complications by severity. This r
etrospective cohort study examined the incidence, types, and severity
of problems that interrupt rehabilitation and the major risk factors f
or these events. Results: Of 1075 patients, 359 (33.4%) had acute medi
cal complications on rehabilitation considered severe enough to interr
upt treatment. Of the 359 patients, 158 (44%) required an unexpected t
ransfer off rehabilitation. The most common reasons for unexpected tra
nsfer were surgical causes (22.8%), followed by infection or fever (17
.1%) and by thromboembolic events (16.5%). Logistic regression reveale
d that major risk factors for complications requiring transfer were a
primary diagnosis of deconditioning or nontraumatic spinal cord injury
(adjusted odds ratio, 2.7; confidence interval, 1.8 to 4.2), severity
of initial disability (adjusted odds ratio, 1.2; confidence interval,
1.1 to 1.3 for every 10-point drop in a Modified Barthel Index), and
number of comorbid conditions (adjusted odds ratio, 1.1; confidence in
terval, 1.0 to 1.2). Risk factors for any complication were similar, b
ut there was an interaction between comorbidity and the degree of func
tional impairment; in patients who were severely functionally impaired
, the number of comorbidities was not as strongly associated with the
risk of complications as it was in patients who were less functionally
impaired. Conclusion: There is a complex relationship among the type
of underlying medical impairment, severity of functional limitation, c
omorbidity, and unanticipated medical or surgical complications that i
nterrupt rehabilitation. The interruptions vary both in type and in se
verity.