There is now ample evidence from both experimental and computer simula
tion studies that in displacement cascades not only intense recombinat
ion takes place but also efficient clustering of both self-interstitia
l atoms (SIAs) and vacancies. The size distributions of the two types
of defects produced in cascades are not only different but this differ
ence is also temperature dependent because of the different thermal st
abilities of SIA and vacancy clusters. This asymmetry in the productio
n of SIAs and vacancies has been termed ''production bias''. In the pr
esent paper, the basic physics of the defect reactions kinetics associ
ated with the specific features of cascade damage is described, with e
mphasis on asymmetries between SIA and vacancy type defects concerning
their production, stability, mobility and interactions with other def
ects. Defect accumulation under cascade damage conditions is discussed
in terms of this reaction kinetics taking into account cluster produc
tion, dissociation, migration and annihilation at extended sinks. Micr
ostructural features which are characteristic of cascade damage and ca
nnot be explained in terms of the conventional single defect reaction
kinetics are emphasized, in particular the heterogeneous microstructur
al evolution at low doses and the dose and temperature dependence of s
welling.