For some materials, neutron-induced transmutations are predicted to le
ad to substantial changes in elemental composition over neutron exposu
re times comparable to expected component service lives. These changes
involve the partial burnup of elements initially present and the accu
mulation of transmutation products, to a point at which materials prop
erties may be adversely affected. Tantalum, tungsten and the alloy W-2
6Re are studied as examples and allowance is made in inventory predict
ions for 'self-shielding' effects that are found to be important in th
ese materials. The evolution of elemental compositions is examined as
a function of exposure time and the implications for materials propert
ies are briefly discussed.