THE STABILITY OF DUPLEX DNA CONTAINING 3,N-4-ETHENO-2'-DEOXYCYTIDINE (EPSILON-DC) - A UV MELTING AND HIGH-RESOLUTION H-1-NMR STUDY

Authors
GIBSON NJ PARKINSON JA BARLOW T WATSON WP BROWN T
Citation
Nj. Gibson et al., THE STABILITY OF DUPLEX DNA CONTAINING 3,N-4-ETHENO-2'-DEOXYCYTIDINE (EPSILON-DC) - A UV MELTING AND HIGH-RESOLUTION H-1-NMR STUDY, Journal of the Chemical Society, Chemical Communications, (19), 1994, pp. 2241-2242
Citations number
12
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
19
Year of publication
1994
Pages
2241 - 2242
Database
ISI
SICI code
0022-4936(1994):19<2241:TSODDC>2.0.ZU;2-T
Abstract
The mutagenic lesion 3,N-4-etheno-2'-deoxycytidine (epsilon dC) greatl y destabilises DNA when paired with each of the natural bases although the solution structure of a duplex containing a epsilon C : A pair sh ows that the lesion does not greatly disrupt base pairing in the duple x.