KINETICS OF SPIRAMYCIN METRONIDAZOLE (RODOGYL(R)) IN HUMAN GINGIVAL CREVICULAR FLUID, SALIVA AND BLOOD

The peripheral distribution of spiramycin and metronidazole, which are combined in the proprietary drug ''Rodogyl(R)'', has been studied in gingival fluid, saliva and blood after a single administration to 12 h ealthy volunteers and after repeated administration to 4 patients with recurring severe periodontitis. Analysis of the 2 antibiotics have be en performed at regular intervals during the 24-h period immediately f ollowing the administration to the volunteers and after the 1st and th e 15th days of repeated administration to the patients. The results sh ow that gingival fluid contains concentrations of spiramycin and metro nidazole higher than those needed to inhibit the growth of periodontop athic bacteria. Spiramycin was found at higher concentrations in GCF t han in blood, although this feature was not found for metronidazole, w hich was administered simoultaneously and showed similar concentration s in both fluid and serum. Such high concentrations persist for a long time, and suggest the potential of this compound in the treatment of severe cases of periodontitis.