Y. Vazquezmazariego et al., BURKITT-LYMPHOMA WITH A DUPLICATION OF DER(8)T(2,8) - INTERPRETATION OF A COMPLEX KARYOTYPE BY CHROMOSOME PAINTING, Cancer genetics and cytogenetics, 76(2), 1994, pp. 136-139
A 51-year-old male patient was diagnosed with Burkitt lymphoma 3 month
s after cardiac transplantation. The bone marrow karyotype was very co
mplex, and to better define the complex karyotype we used the in situ
suppression hybridization technique. Previously we interpreted this ka
ryotype to be: 48,XY;t(2;8) (p11;q24), +der(2)t(2;8)(p11;q24),del(2)(q
23), +7, +der(8)t(2;8)(p11;q24), +12, -13, -18, by G banding technique
s, with a duplication of the t(2;8) derivatives. After in situ hybridi
zation we changed to a: 48,XY,t(2;8)(p11;q24),t(2;18)(q23;q22), +7, der(8)t(2;8) (p11;q24), +12, -13, which implies duplication of only on
e t(2;8) derivative.