L-NAME AUGMENTS THE ANTINOCICEPTIVE EFFECTS OF INTRACEREBROVENTRICULARLY APPLIED ET-1 AND ET-3

Authors
MASLAROVA J NIKOLOV R SEMKOVA I
Citation
J. Maslarova et al., L-NAME AUGMENTS THE ANTINOCICEPTIVE EFFECTS OF INTRACEREBROVENTRICULARLY APPLIED ET-1 AND ET-3, Methods and findings in experimental and clinical pharmacology, 16(6), 1994, pp. 387-390
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Methods and findings in experimental and clinical pharmacology → ACNP
ISSN journal
03790355
Volume
16
Issue
6
Year of publication
1994
Pages
387 - 390
Database
ISI
SICI code
0379-0355(1994)16:6<387:LATAEO>2.0.ZU;2-1
Abstract
The interaction between endothelin-1 (ET-1) (5 pmol/mouse, i.c.v.) and endothelin-3(ET-3) (5 pmol/mouse, i.c.v.) with N-G-nitro-L-arginine m ethyl ester (L-NAME) (5 mg/kg i.p., 30 min pretreatment) was investiga ted in mice by the use of two experimental procedures: hot plate and t ail flick tests in mice. L-NAME showed slight insignificant antinocice ptive action, but augmented significantly the antinociceptive effects of i.c.v. administered ET-1 and ET-3 in both experimental tests.