SYNTHESIS OF PYRAZOLO[1,5-A]PYRIDINES AND PYRAZOLO[1,5-C]PYRIMIDINES BY REACTION OF HETEROCYCLIC AMIDRAZONES WITH 1,3-DICARBONYL COMPOUNDS

Authors
KOCKRITZ P RIEMER B MICHLER A HASSOUN A LIEBSCHER J
Citation
P. Kockritz et al., SYNTHESIS OF PYRAZOLO[1,5-A]PYRIDINES AND PYRAZOLO[1,5-C]PYRIMIDINES BY REACTION OF HETEROCYCLIC AMIDRAZONES WITH 1,3-DICARBONYL COMPOUNDS, Journal of heterocyclic chemistry, 31(5), 1994, pp. 1157-1160
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
31
Issue
5
Year of publication
1994
Pages
1157 - 1160
Database
ISI
SICI code
0022-152X(1994)31:5<1157:SOPAPB>2.0.ZU;2-5
Abstract
1,3-Dicarbonyl compounds 2 react with 1-amino-2(1H)-pyridin-2-imines o r 1-amino-2(1H)-pyrimidin-2-imines 1 giving new pyrazolo[1,5-a]pyridin es or pyrazolo[1,5-c]pyrimidines 5 respectively by addition, oxidation and condensation. Isolation of an intermediate 3 shows that surprisin gly the addition of the CH acidic 1,3-dicarbonyl compound to position 6 of the pyrimidine 1 is the initial step.