Citation
St. Sawyer et K. Penta, ERYTHROPOIETIN CELL BIOLOGY, Hematology/oncology clinics of North America, 8(5), 1994, pp. 895
Citations number
68
Categorie Soggetti
Oncology,Hematology
Journal title
ISSN journal
08898588
Volume
8
Issue
5
Year of publication
1994
Database
ISI
SICI code
0889-8588(1994)8:5<895:ECB>2.0.ZU;2-C
Abstract
Erythropoietin (EPO) mediates its biologic actions in responsive cells
through the 78 kDa cell surface form of the EPO receptor. The biosynt
hesis, activations, and destruction of EPO receptors are described. Th
e binding of EPO to its receptor leads to the activation of a tyrosine
protein kinase(s) that results in the phosphorylation of the receptor
and other proteins.