RECURRENT OVARIAN SEX CORD TUMOR WITH ANNULAR TUBULES - TUMOR-MARKER AND CHEMOTHERAPY EXPERIENCE

Recurrent sex cord tumor with annular tubules is an unusual ovarian ca ncer. The authors report a patient with recurrent disease that was ult imately followed with multiple tumor markers. During this period the p atient was treated only with chemotherapy. Her regimen consisted of a combination of etoposide, bleomycin, and cisplatin. The tumor markers that were followed were CA-125, CEA, inhibin, and Mullerian-inhibiting substance (MIS). There was no elevation of the CA-125 or CEA, but inh ibin and MIS proved to be effective markers. Serum inhibin and MIS cor related perfectly with her documented disease status and was brought i nto the normal range when the patient was disease-free. This disease-f ree status was proven by surgical reexploration. This report is the fi rst documented complete response in this rare malignancy treated by ch emotherapy alone with distant metastatic spread. It also gives strong linkage of inhibin and MIS as good markers in this particularly rare m alignancy. (C) 1994 Academic Press, Inc.