Wh. Vanbrakel et Ib. Khawas, NERVE DAMAGE IN LEPROSY - AN EPIDEMIOLOGIC AND CLINICAL-STUDY OF 396 PATIENTS IN WEST NEPAL .1. DEFINITIONS, METHODS AND FREQUENCIES, Leprosy review, 65(3), 1994, pp. 204-221
A historic cohort study was performed to determine the prevalence and
incidence rates of nerve function impairment (NFI) as demonstrated by
sensory testing with a nylon monofilament and standard tests of motor
function. The records of 396 new leprosy patients registering at Green
Pastures Hospital, Pokhara, between January 1988 and January 1992 wer
e analysed. The mean follow-up period was 21 months. In all, 36% (141/
396) of patients had either sensory or motor function impairment at th
eir initial examination. For each nerve the prevalence of sensory and
motor impairment is reported separately. The posterior tibial nerve wa
s the most frequently affected (sensory) nerve (21%). Sensory impairme
nt of the ulnar nerve was found in 17% of the patients; 8.8% had senso
ry impairment of the median nerve. The overall incidence rate of motor
function impairment was 7.5 (5.4-10) per 100 person years at risk (PY
AR). Sensory impairment had a significantly higher rate of 13 (10-17)/
100 PYAR (rate ratio (1.8 (1.2-2.7), p = 0.0076). Bl patients had a si
gnificantly higher incidence rate of nerve function impairment than BT
patients (rate ratio 2.3 (1.4-3 .7), p = 0.006). Altogether 152/396 (
39%) of the patients required corticosteroid treatment for 'recent' or
'acquired' impairment, and 78 of the patients (20%) developed severe
nerve function impairment during or after antileprosy treatment. Analy
sis of potential risk factors for nerve function impairment showed a s
ignificant association with the extent of clinical disease expressed a
s the number of body areas (out of 9) with primary or secondary signs
of leprosy (rate ratio 5.0 (1.5-17), p = 0.0091). It was concluded tha
t nerve function impairment is a serious problem, often occurring duri
ng or after multidrug therapy. The extent of clinical disease expresse
d as a count of body areas involved, or of skin or nerve lesions may i
dentify patients who are at increased risk of nerve damage.