The objective of this study was to determine the role of antineural an
tibodies in leprosy. Indirect ELISA using antigen prepared from normal
human peripheral nerves was carried out on the sera from 100 leprosy
patients and 18 normal controls. In total, 9% of the patients had demo
nstrable levels of IgG antineural antibodies and 11% had demonstrable
levels of IgM antibodies. There was no correlation with the type of le
prosy, baeteriological index, treatment taken, the presence of a react
ional state, the presence of enlarged nerves or active neuritis.