A PLACEBO-CONTROLLED RANDOMIZED TRIAL OF THE TERBUTALINE PUMP FOR PREVENTION OF PRETERM DELIVERY

To determine the efficacy of the terbutaline pump for the prevention o f preterm delivery, patients in preterm labor defined by progressive c ervical change underwent intravenous magnesium sulfate tocolysis (with or without oral indomethacin, as necessary), and once labor was arres ted, were randomized to one of three treatment arms: terbutaline by pu mp, saline by pump (blinded), or oral terbutaline. If recurrent preter m labor occurred despite maximization of therapy, the treatment arm wa s determined and therapy was changed; saline pump and oral terbutaline were switched to terbutaline pump, terbutaline pump was switched to o ral terbutaline. Patients who continued to labor were readmitted for a ggressive intravenous therapy. Women randomized to the terbutaline pum p (n = 15), saline pump (n = 12), and oral terbutaline (n = 15) groups were similar in terms of gravidity, parity, days of tocolysis before study entry, gestational age at entry, and cervical dilatation at entr y. The mean gestational age at delivery was the same in all three grou ps (35 weeks), as were neonatal outcomes. Terbutaline by pump, saline by pump, and oral terbutaline appear equivalent for the prevention of preterm delivery. The terbutaline pump should remain experimental.