FATAL HEPATIC VENOOCCLUSIVE DISEASE IN A NEWBORN-INFANT

We describe a newborn infant with veno-occlusive disease (VOD) of the liver. Prior to discharge from the hospital, the newborn, who had been treated for suspected neonatal infection, suddenly developed sepsis-l ike symptoms. The size of the liver as well as serum activity of hepat ic enzymes increased progressively. Initial Doppler-flow studies demon strated an absent flow in the vena portae, a finding that was compatib le with vena portae thrombosis or occlusion of other hepatic veins. A therapy with recombinant tissue plasminogen activator (rt-PA) was init iated; due to extensive bleedings from various sides, the fibrinolytic therapy had to be withdrawn 12 hours later, when Doppler-flow examina tion revealed a reverse flow in hepatofugal direction. Despite support ive therapy, the general condition of the patient deteriorated continu ously, finally resulting in liver and renal failure. Our patient died 19 days after birth. The autopsy demonstrated obliterative lesions of the centrilobular and sublobular hepatic veins, the classical signs of VOD of the liver. Despite extensive diagnostics and examinations, the etiology of VOD could not been elucidated in this newborn.