Sv. Savelev et al., TRANSPLANTATION OF FETAL NERVE-CELLS FROM INSECTS TO THE BRAIN OF AMPHIBIANS AND MAMMALS, Bulletin of experimental biology and medicine, 117(4), 1994, pp. 365-369
Cells of the neural primordia of the Notch mutant of Drosophila melano
gaster transplanted to the neural tube of four amphibian species and t
wo mammalian species. It is shown that cells of the neural primordia o
f drosophila survive and differentiate In the amphibian and mammalian
brain. Differentiated cells of the transplant establish axon-dendrite
junctions with cells of the recipient and penetrate into the structure
s of its brain. Tailed amphibians die several days after xenotransplan
tation. Transplantation of drosophila cells to the nervous system of t
ailless amphibians and mammals does not cause developmental abnormalit
ies or death of the animals.