TRANSPLANTATION OF FETAL NERVE-CELLS FROM INSECTS TO THE BRAIN OF AMPHIBIANS AND MAMMALS

Cells of the neural primordia of the Notch mutant of Drosophila melano gaster transplanted to the neural tube of four amphibian species and t wo mammalian species. It is shown that cells of the neural primordia o f drosophila survive and differentiate In the amphibian and mammalian brain. Differentiated cells of the transplant establish axon-dendrite junctions with cells of the recipient and penetrate into the structure s of its brain. Tailed amphibians die several days after xenotransplan tation. Transplantation of drosophila cells to the nervous system of t ailless amphibians and mammals does not cause developmental abnormalit ies or death of the animals.