Sv. Savelev et al., TRANSPLANTATION OF FETAL AND XENOGENEIC NERVOUS-TISSUE IN PARKINSONS-DISEASE, Bulletin of experimental biology and medicine, 117(4), 1994, pp. 370-373
A mixture of fetal human brain tissue and of neural primordia of Notch
Drosophila melanogaster is transplanted to the ventrolateral thalamic
nucleus of patients with Parkinson's disease in stage 3-4. Two kinds
of operation are performed. In the first case cryodestruction of the z
one of tissue implantation is performed before transplant, and in the
second case this procedure is not performed. A stable effect manifeste
d in the disappearance of tremor and rigidity is achieved for both kin
ds of operation. When a transplant is performed without cryodestructio
n, the effect does not manifest itself until 2 months postoperation. T
he patients are followed up for 7-12 months postoperation. No side eff
ects or relapses of Parkinson's disease are observed in this period.