COMPARATIVE KINETIC-STUDY OF THE BINDING BETWEEN 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN AND RELATED LIGANDS WITH THE HEPATIC AH RECEPTORS FROMSEVERAL RODENT SPECIES

Kinetic analysis of the time course of association of [H-3]-2,3,7,8-te trachlorodibenzo-p-dioxin with hepatic cytosol from five rodent specie s gave additional evidence for differences in the properties of the Ah receptor ligand binding subunit between species. A parallel study of the association of six tritiated polychlorinated dibenzo-p-dioxins and dibenzofurans with hepatic Ah receptor from Wistar rat and C57BL/6 mo use showed that their rank order for kinetic affinity did not correlat e with the rank ordering of their toxic potency and may vary according to the source of the Ah receptor.