IMMUNOPHENOTYPING AND METASTATIC LOCALIZATION OF BREAST-CANCER

Monoclonal antibody SM 92 is involved in the immunophenotype of gastro intestinal and liver cells, SM 43 in ovarian cells, and SM 13 in lung cells. Based on a study of 61 breast adenocarcinoma patients, we found that tumors reacting with SM 92 appear associated with liver metastas es, SM 43 with ovarian metastases, and SM 13 with lung metastases. The se associations are highly significant. They lend some support to the concept that tumor cells that metastasize tend to go to sites where ce lls normally have the same surface antigens.