BILATERAL CEREBRAL MEDIOFRONTAL HYPOACTIVITY IN TC-99M HMPAO SPECT IMAGING

Fifteen patients who had bilateral mediofrontal hypoactivity and 30 co ntrol subjects without this SPECT anomaly underwent Tc-99m HMPAO brain SPECT imaging. Bilateral mediofrontal hypoactivity was found in vario us neurologic disorders, including subcortical arteriosclerotic enceph alopathy, lacunar state, chronic alcoholism, progressive nonvascular d ementia, carbon monoxide poisoning, and diabetes mellitus. This SPECT abnormality was, however, specifically associated with three clinical signs: motor disabilities predominating in the lower limbs, urinary in continence, and akinetic mutism.