The authors report the case of a 15-year-old female suffering from bil
ateral keratitis revealing Lyme's disease, 6 years after a tick bite.
The corneas disclosed multiple hazy infiltrates adjacent to the limbus
and in the midperiphery, form the superficial layers to pre-Descemet'
s membrane. The other systems involved were the joints, the skin (an a
typical erythema chronicum migrans), and perhaps the peripheral nerves
. The diagnosis was confirmed by indirect immunofluorescence assays in
the serum of the patient who completely and rapidly healed with amoxi
cillin and systemic and topical steroids. The clinical and serological
pitfalls which explain the frequent delayed diagnosis of Lyme's disea
se, its complications, especially ocular, and the therapeutic strategi
es are discussed.