MOLECULAR MODELING AND SYNTHESIS OF BOC-ALA-GLY-OET BY ACTIVE ESTERS WITH TERPENIC HYDROXYIMIDES

''Active esters'' of Boc-D-alanine and terpenic derivatives of the suc cinic acid N-hydroxyimide (2 and 3) react with the Gly-OExHCl in the p resence of the Et3N yielding optically pure D-dipeptides. As it was de termined experimentally and also supported by molecular modelling and energy calculations, the role of terpenic part involves epimerization of the potentially racemizing part of the substrate to desirable direc tion.