RADIO-IMMUNOTHERAPY DOSIMETRY WITH SPECIAL EMPHASIS ON SPECT QUANTIFICATION AND EXTRACORPOREAL IMMUNO-ADSORPTION

Results from therapeutic trials with radiolabelled monoclonal antibodi es are difficult to compare, because of lack of accurate macroscopic a nd microscopic dosimetry for both tumours and normal tissues. Requirem ents for such a dosimetry are covered in the paper. Accurate in vivo d osimetric measurement techniques for verification of calculated absorb ed doses are also needed to verify treatment planning. In the review, important topics related to dosimetry in therapeutic trials in RIT are covered, such as, absorbed-dose calculations and activity-quantificat ion techniques for planar imaging and SPECT. The latter is particularl y discussed, including a summary of different correction techniques. A bsorbed-dose calculations and treatment-planning techniques are also d iscussed. possible ways extracorporeal immuno-adsorption. The review c ould form the basis of the development of future treatment-planning pr otocols and for dosimetry calculations in radio-immunotherapy, conside ring some of the most important parameters for approaching an accurate in vivo dosimetry.