RETROVIRAL INHIBITION BY ANTISENSE OLIGONUCLEOTIDES DETERMINED BY INTRACELLULAR STABILITY

Authors
ROPERT C OKRUSZEK A COUVREUR P MALVY C
Citation
C. Ropert et al., RETROVIRAL INHIBITION BY ANTISENSE OLIGONUCLEOTIDES DETERMINED BY INTRACELLULAR STABILITY, Antisense research and development, 4(3), 1994, pp. 207-210
Citations number
15
Categorie Soggetti
Medicine, Research & Experimental","Biothechnology & Applied Migrobiology
Journal title
Antisense research and development → ACNP
ISSN journal
10505261
Volume
4
Issue
3
Year of publication
1994
Pages
207 - 210
Database
ISI
SICI code
1050-5261(1994)4:3<207:RIBAOD>2.0.ZU;2-7
Abstract
A 15-mer oligodeoxyribonucleotide was found to be efficient toward the Friend retrovirus only when modified. or encapsulated in liposomes. T he nonmodified oligomer was inefficient. We have measured the intracel lular stability of this 15-mer when encapsulated or modified and we ha ve observed a direct relationship between the intracellular stability of the oligonucleotides and their antiretroviral efficiency.