ASSOCIATION OF PANCREATIC ADENOCARCINOMA, MILD LUNG-DISEASE, AND DELTA-F508 MUTATION IN A CYSTIC-FIBROSIS PATIENT

A case of adenocarcinoma of the pancreas and mild lung disease in a 39 -year-old man homozygous for the Delta F508 cystic fibrosis mutation i s presented. Cystic fibrosis is the most common lethal genetic disease in Caucasians, and is most commonly associated with severe obstructiv e lung disease. To our knowledge, this is only the fifth case of adeno carcinoma of the pancreas in a CF patient to be reported and the first case for which molecular data are available. The rare incidence of th is type of malignancy in the general population suggests a possible as sociation of CF with this malignant disease.