GLYCOGEN DEPLETION DURING COLD ISCHEMIC LIVER PRESERVATION

Data on glycogenolysis during hypothermic storage of rat liver have be en obtained over 24h at 0-2 degrees C. There was a steady decline in l iver glycogen during 24h in livers stored after flush with either citr ate-based or lactobionate-based preservation solutions. Adding glucose or insulin to the preservation solution was without effect on glycoge nolysis, but a combination of added glucose plus insulin prevented gly cogenolysis. The results are discussed in relation to activation of gl ycogenolysis during the initial flush procedure.