Background: The purpose of this study was to evaluate the outcome of p
atients undergoing laparoscopic splenectomy (LS) at the University of
California, San Francisco, Methods: The medical records of the initial
52 unselected patients undergoing LS were reviewed and compared to 28
concurrently treated open splenectomy patients (OS), Results: Patient
s did not differ with regard to age, gender, body, or splenic weights,
The operative time was longer in the LS patients (mean 196 vs 156 min
), but the length of stay and duration of ileus were shorter in the LS
group, For adult patients admitted exclusively for splenectomy, opera
tive times did not differ between LS and OS and total hospital cost wa
s less in the LS group (mean $8,939 vs $14,022). Six patients required
conversion to OS, four occurring in the first 11 patients treated (ov
erall conversion rate of 11%). Three patients died from complications
related to their underlying disease. Two other major complications occ
urred, Complication rates and transfusion requirements did not differ
between OS and LS patients, Conclusions: Laparoscopic splenectomy is a
safe and effective alternative to open splenectomy for treatment of h
ematologic diseases in patients of all ages.