SUCCESSFUL THERAPY FOR CEREBRAL PHEOHYPHOMYCOSIS DUE TO DACTYLARIA-GALLOPAVA IN A LIVER-TRANSPLANT RECIPIENT

A 68-year-old liver transplant recipient who was being treated with FK 506 and immunosuppressive steroid therapy was admitted to our medical center because of a tonic-clonic seizure. Computed tomography of the head revealed multiple discrete cerebral abscesses, and culture of flu id drained intraoperatively yielded a dematiaceous fungus. The isolate was susceptible to amphotericin B and itraconazole but was resistant to flucytosine and fluconazole. The patient was successfully treated w ith a prolonged course of amphotericin B colloidal dispersion and itra conazole, as evidenced by both clinical and radiographic resolution of disease over a 2-year follow-up.