TREATMENT WITH INTRALESIONAL GRANULOCYTE INSTILLATIONS AND INTERFERON-GAMMA FOR A PATIENT WITH CHRONIC GRANULOMATOUS-DISEASE AND MULTIPLE HEPATIC-ABSCESSES

We present the case of a 16-year-old girl with p22(phox)-deficient chr onic granulomatous disease in whom multiple hepatic abscesses secondar y to Staphylococcus aureus infection developed. Infection persisted de spite extensive surgery and aggressive antibiotic therapy. Conventiona l intravenous granulocyte transfusions were not tolerated because of t he development of alloantibodies to HLA. Treatment with interferon-gam ma and intralesional granulocyte infusions was associated with dramati c clinical and radiographic improvement. No morbidity was associated w ith this therapy. To our knowledge, this is the first report of treatm ent with intralesional granulocyte instillations. Intralesional granul ocyte instillation in association with interferon-gamma administration may result in clinical improvement in the conditions of patients with chronic granulomatous disease and hepatic abscesses for whom conventi onal therapy has failed.