An oncocytoma of the upper eyelid that occurred in an 82-year-old male
was studied immunohistologically according to the avidin-biotin-perox
idase complex method (secretory component, carbohydrate antigen 19-9,
carcinoembryonic antigen, anticytokeratin AE1/AE3, S-100 protein, myog
lobin, actin, vimentin). The staining properties of columnar-type onco
cytes were the same as those of epithelial cells of excretory ducts of
Moll's gland, but those of polygonal-type oncocytes were similar to t
hose of myoepithelial cells of Moll's gland. Our results suggested tha
t excretory duct epithelial cells of Moll's gland are the origin of on
cocytoma of the eyelid.